服用肌酸对肌肉运动能力的影响

目的 研究增加肌酸摄入量后肌肉组织中肌酸和肌酸激酶（ｃｒｅａｔｉｎｅ ｋｉｎａｓｅ,ＣＫ）含量的变化,探讨补充肌酸对肌肉工作能力的影响。方法 小鼠饲养１周后,取得肌肉提取液,用联乙酰－α奈酚反应测定法和逆向反应肌酸比色法分别测定肌酸和ＣＫ的含量。结果 实验组和对照组肌酸和ＣＫ含量经ｔ检验（Ｐ〈０．０１）,差异显著。结论 增加肌酸摄入量,能改善肌肉生化基础,增强组织细胞代谢能力。     

早期康复护理对脑卒中患者日常生活能力的影响

目的：为了检验早期康复护理对脑卒中患日常生活能力（ＡＤＬ）的影响,本对比观察了早期介入康复护理和一般临床护理（以下简称对照组）两组病例。结果：发现早期介入康复护理患的肩痛、肩手综合症的发生率较一般护理组明显降低（Ｐ〈０．０１）,Ｂ指数康复护理组较一般护理组明显提高（Ｐ〈０．０１）,而肩关节脱位发生率两组之间无明显差异（Ｐ〉０．０５）。结论：说明早期介入康复护理能明显提高脑卒患的日常生活能力     

高原训练期间军人认知功能的追踪研究

目的:研究高原训练军人的认知功能变化特点及其 影响因素.方法:采用选数测验、连续计算测验、符号认知测 验,对某进藏训练部队的50名军人进行连续测评,对不同海拔高度、进入高原不同时间和不同军事作业阶段,军人的各种 认知功能进行动态跟踪研究.结果:①不同海拔各认知作业 完成率均显示显著差异(P<0.05);②除选数测验外,进入高 原不同时间各认知作业完成率均有显著差异(P<0.01);③ 各认知作业完成率,不同军事作业阶段,选数测验有显著差异 (P<0.05),连续计算和符号认知有非常显著的差异(P< 0.01);④各认知任务的作业正确率,不同海拔、进入高原不同 时间、不同军事作业阶段均有非常显著的差异(P<0.01). 结论:高原环境对军人认知功能产生明显影响,这种影响与海 拔高度、进入高原时间与军事作业状态均有明显关系.     

根管预备不同器械对根管充填根尖孔封闭性的影响

目的研究两种临床常用的根管预备器械不锈钢锉和镍钛锉预备根管对充填后根管根尖孔封闭性的影响。方法选取仿真树脂根管30个,随机分为3组:逐步后退法预备组:采用不锈钢锉预备根管;冠根向法预备组:手用镍钛锉预备根管;对照组。AHPLUS根充糊剂加牙胶尖冷测压法充填,染料渗透法评价,分别在第3,5,7,9,11天定时观察,记录染料渗漏的发生率以及染料渗漏的程度。结果第3,5,7,9,11天,逐步后退法预备组染料渗漏率分别为30%,30%,60%,60%,70%;冠根向法预备组分别为0,0,20%,20%,30%;逐步后退法预备组染料在根管内渗漏程度分别为(0.46±0.21)mm,(0.78±0.11)mm,(0.64±0.47)mm,(0.81±0.55)mm,(0.90±0.63)mm;冠根向法预备组分别为0,0,(0.37±0.16)mm,(0.48±0.11)mm,(0.56±0.19)mm,第3,5天逐步后退法预备组的染料渗漏率以及染料渗漏的程度与冠根向法预备组间差异有统计学意义(P<0.05),而在第7,9,11天两组间差异无统计学意义(P>0.05)。结论短期内冠根向预备技术比逐步后退技术成形的根管更有利于根管充填后根尖孔的密封。     

Oxidative ability and toxicity of n-hexane insoluble fraction of diesel exhaust particles.

Diesel exhaust particles (DEP) are known to induce adverse biological responses such as inflammation of the airway. However, the relationship between the chemical characteristics of organic compounds adsorbed on DEP and their biological effects is not yet fully understood. In this study, the dichloromethane-soluble fraction (DMSF) from DEP was fractionated into its n-hexane-soluble fraction (n-HSF) and n-hexane-insoluble fraction (n-HISF). Using these DEP fractions, we designed the present studies to elucidate (1) chemical characteristics, (2) biological characteristics, and (3) the relationship between the chemical and the biological characteristics of these DEP fractions. Dithiothreitol (DTT) assay, Fourier transform-infrared (FT-IR) spectroscopy, proton nuclear magnetic resonance (1H-NMR) spectroscopy, and gas chromatography-mass spectrometry (GC-MS) were used to characterize their chemical properties. Heme oxygenase-1 (HO-1) protein expression, viability of rat alveolar type II epithelial cell line (SV40T2), and inflammatory cell infiltration into the peritoneal cavity of BALB/c mice were evaluated as markers of oxidative stress, cytotoxicity, and inflammatory response, respectively. The oxidative ability of the DEP fractions was n-HISF > DMSF > n-HSF. IR, 1H-NMR, and GC-MS spectra showed that n-HISF was mainly composed of compounds having many functional groups related to oxygenation, such as hydroxyl and carbonyl groups. The relative strength of HO-1 protein expression, cytotoxicity, and inflammatory responses was also n-HISF > DMSF > n-HSF. All of the n-HISF-induced biological activities were decreased by reduction with N-acetyl-L-cysteine (NAC). These results suggest that n-HISF has high oxidative ability and many functional groups related to oxygenation and that this ability strongly contributes to the induction of oxidative stress, cytotoxicity, and inflammatory response.     

慢性肾炎肾虚证患者红细胞变形能力改变的临床研究

目的为了探索肾虚证红细胞变形能力的相关性,我们采用激光衍射的方法。方法选择临床上慢性肾为肾阴虚证与肾阳虚证患者为研究对象,设正常人为对照组,对其血红细胞变形能力(用红细胞变形指数表示)进行了临床观察。结果在所观察的慢性肾炎96例病人中肾阴虚与肾阳虚两组血红细胞变形指数均低于正常人(均P <0 .0 1) ;肾阴虚证与肾阳虚证两组间比较肾阴虚证偏低(P <0 .0 1)。结论肾阴虚证与肾阳虚证患者均有红细胞变形能力损伤。     

精神分裂症患者责任能力与P300电位及人格因素的关系

目的探讨P300电位及人格测定在精神分裂症司法鉴定责任能力评定中的价值。方法对110名经司法鉴定为无或限定责任能力的精神分裂症患者及60名正常者进行了P300电位及艾森克个性问卷(EPQ)测定,并将结果加以比较。结果无责任能力组及限定责任能力组的精神分裂症患者P300电位中N2[(266.5±24.5)ms、(248.0±22.9)ms]和P3[(369.2±28.3)ms、(341.6±26.9)ms]潜伏期和P3[(2.2±1.1)μV、(4.8±1.5)μV]波幅较正常组显著延长和降低(P<0.01或P<0.05),其中无责任能力精神分裂症患者组P300电位成分中N2及P3潜伏期较限定责任能力组延长,P3波幅降低,差异有显著性(P<0.05)。无或限定责任能力的精神分裂症患者EPQ中精神质[(10.38±3.40)分、(9.75±3.57)分]和神经质[(14.76±4.42)分、(13.38±4.04)分]2个纬度的量表分明显高于正常组(P<0.01或P<0.05),而无责任能力组EPQ中神经质的量表分值明显高于限定责任能力组(P<0.05)。结论P300电位及EPQ问卷在精神分裂症司法鉴定责任能力评定中有较高的参考价值。     

Rehabilitation of a periodontal patient with rapidly progressing marginal alveolar bone loss: 1-year follow-up

BACKGROUND: The present case report describes a 1-year follow-up of functional rehabilitation of a young periodontal patient with severely advanced, rapidly progressing marginal bone loss treated by using a new splinting material, i.e., glass fiber-reinforced composite (FRC). Apart from one single tooth, the young man had retained all his natural teeth. TREATMENT: Periodontal treatment was based on cleaning and root planing enabled by partial-thickness-flap operations. This method was selected to avoid further damage to the remaining alveolar bone. After healing for 6 months, a cavity retained internal FRC splint was constructed and 1 missing lower molar was replaced by an inlay-retained FRC resin-bonded fixed partial denture (FPD). A 12 months follow-up period revealed a healthy periodontium and good functional and esthetic results. CONCLUSIONS: The new material allows the use of periodontal treatment methods instead of prosthetic alternatives, which until now have been a more generally used approach in the treatment of severely advanced periodontal cases. Internal fiber-reinforced composite splinting being affordable for the patient, easy for the clinician to construct and giving good esthetic and functional results, suggests that the method may be a valuable aid in periodontal treatment.     

Clinical outcomes of three Parkinson's disease patients treated with mandibular implant overdentures

Parkinson's disease (PD) often affects the oro-pharyngeal musculature, leading to problems with speaking, chewing and swallowing. The inevitable reduction in food and fluid intake contributes to the further deterioration of neurological symptoms. Parkinson's disease patients have great difficulties in adjusting to the use of complete dentures. It is the purpose of this report to evaluate the benefit of using dental implants combined with overdentures to improve chewing and predigestion capacity in severely handicapped PD patients. Three edentulous PD patients (2 male, 1 female; mean age 75.7 years; mean PD duration 4.3 years; PD severity grade III according to Hoehn and Yahr; mean edentulousness 19.3 years) complaining of poor chewing ability were included in this evaluation. One-stage dental implants were placed in the interforaminal region of the mandible. After completion of healing, new overdentures were fabricated. Custom-made non-rigid (resilient) telescopic attachments were used for retention of the overdentures on the implants. Follow-up examinations of the 3 patients were made between 28 and 42 months after the completion of treatment, and peri-implant tissue conditions as well as the patients' self-assessed satisfaction level were recorded. A modified gastrointestinal symptoms questionnaire, Hoehn and Yahr Scale and body weight measurements were used to monitor gastrointestinal impairment and PD severity. The peri-implant parameters indicated healthy soft tissue conditions and all Periotest values were in the negative range. The patients judged their chewing abilities to be greatly improved. Since placing the implants, PD severity had deteriorated to grade IV (Hoehn and Yahr scale) in 2 patients and was stable in 1 patient. The body weight had improved slightly in all patients (mean 2.2 kg). On the gastrointestinal scale, all patients had improved from a mean score of 8.7 to 5.7. Non-rigid telescopic attachments for overdenture stabilization are particularly suitable for PD patients as they are easy to handle and to clean. The patients reported remarkable improvement in their chewing ability, an assessment which would seem to be supported by the improved gastro-intestinal index. The regimen described appears to be a useful adjunctive treatment in edentulous Parkinson's disease patients and may be considered for patients with diseases similarly affecting motor skills.     

太白参对小鼠抗氧化能力的影响

ICR小鼠用太白参水煎液灌胃 2 4 d后 ,禁食 16h,随即腹腔注射四氧嘧啶 (15 0 mg/ kg) ,3d后测定 Hb,肝脂数 ,肝脏和血液的 SOD,POD,CAT,MDA,血清 AL T,AST等指标。结果 :1太白参可降低四氧嘧啶引起的肝脏和血液中 SOD,POD,CAT,MDA含量的异常增高。 2太白参可降低四氧嘧啶引起的 Hb增高。 3太白参可增高四氧嘧啶引起的肝脏指数异常下降